Small-molecule ligands can inhibit -1 programmed ribosomal frameshifting in a broad spectrum of coronaviruses
S. Munshi, K. Neupane, S. M. Ileperuma, M. T. Halma, J. A. Kelly, C. F. Halpern, J. D. Dinman, S. Loerch, M. T. Woodside
The paper tests small-molecule ligands against -1 PRF in coronaviruses, finding nafamostat inhibits frameshifting in multiple bat CoVs and SARS-CoV-2 but not other viruses.
bioRxiv · Aug 6, 2021 · PreprintBiochemistry