Author

S. M. Ileperuma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

K. Neupane· 3 shared M. T. Woodside· 3 shared S. Munshi· 3 shared D. B. Ritchie· 2 shared M. Zhao· 2 shared A. Lyons· 1 shared A. Narayan· 1 shared C. F. Halpern· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

K. Neupane

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Author profile →

3 papers

Recent·Most cited

Small-molecule ligands can inhibit -1 programmed ribosomal frameshifting in a broad spectrum of coronaviruses

S. Munshi, K. Neupane, S. M. Ileperuma, M. T. Halma, J. A. Kelly, C. F. Halpern, J. D. Dinman, S. Loerch, M. T. Woodside

The paper tests small-molecule ligands against -1 PRF in coronaviruses, finding nafamostat inhibits frameshifting in multiple bat CoVs and SARS-CoV-2 but not other viruses.

bioRxiv · Aug 6, 2021 · PreprintBiochemistry

Structural dynamics of the SARS-CoV-2 frameshift-stimulatory pseudoknot reveal topologically distinct conformers

K. Neupane, M. Zhao, A. Lyons, S. Munshi, S. M. Ileperuma, D. B. Ritchie, N. Q. Hoffer, A. Narayan, M. T. Woodside

The paper investigates the structural dynamics of the SARS-CoV-2 frameshift-stimulatory pseudoknot under tension, revealing multiple conformers and their folding mechanisms.

bioRxiv · Dec 28, 2020Biophysics

Anti-frameshifting ligand active against SARS coronavirus-2 is resistant to natural mutations of the frameshift-stimulatory pseudoknot

K. Neupane, S. Munshi, M. Zhao, D. B. Ritchie, S. M. Ileperuma, M. T. Woodside

The paper examines how natural mutations in the SARS-CoV-2 pseudoknot affect −1 PRF efficiency and the activity of anti-frameshifting ligands, finding that ligand activity remains resistant to most mutations.

bioRxiv · Jun 29, 2020Biochemistry