Author

C. H. Coelho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

S. Crotty· 3 shared A. Grifoni· 2 shared A. Sette· 2 shared A. Tarke· 2 shared B. Goodwin· 2 shared D. Weiskopf· 2 shared J. M. Dan· 2 shared N. I. Bloom· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

S. Crotty

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5 papers

Recent·Most cited

Giardia intestinalis reshapes mucosal immunity toward a Type 2 response that attenuates inflammatory bowel-like diseases

A. Sardinha-Silva, P. H. Gazzinelli-Guimaraes, O. G. Ajakaye, T. R. Ferreira, E. Alves-Ferreira, E. T. Tjhin, B. Gregg, M. Y. Fink, C. H. Coelho, S. M. Singer, M. E. Grigg

This study shows Giardia intestinalis induces a Type 2 immune response that reduces inflammation in the gut, protecting against inflammatory bowel-like diseases.

bioRxiv · Mar 2, 2024 · PreprintImmunology

SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback

C. H. Coelho, N. Bloom, S. I. Ramirez, U. M. Parikh, A. Heaps, S. F. Sieg, A. Greninger, J. Ritz, C. Moser, J. J. Eron, J. S. Currier, P. Klekotka, D. A. Wohl, E. S. Daar, J. Li, , Accelerating COVID-19 Therapeutic Interventions and Vaccines: 2/A5401 (ACTIV-2/A5401) Study Team

This study shows that SARS-CoV-2 mAb treatment shifts memory B cell epitope recognition, affecting their response to vaccination.

bioRxiv · Nov 21, 2023 · PreprintImmunology

Humoral and cellular immune memory to four COVID-19 vaccines

Z. Zhang, J. Mateus, C. H. Coelho, J. M. Dan, C. R. Moderbacher, R. I. Galvez, F. H. Cortes, A. Grifoni, A. Tarke, J. Chang, E. A. Escarrega, C. Kim, B. Goodwin, N. I. Bloom, A. Frazier, , S. Crotty

This study evaluates immune memory responses to four COVID-19 vaccines over six months, finding stable T and B cell memory but declining neutralizing antibodies with mRNA vaccines.

bioRxiv · Mar 18, 2022Immunology

SARS-CoV-2 vaccination induces immunological memory able to cross-recognize variants from Alpha to Omicron

A. Tarke, C. H. Coelho, Z. Zhang, J. M. Dan, E. D. Yu, N. Methot, N. I. Bloom, B. Goodwin, E. Phillips, S. Mallal, J. Sidney, G. Filaci, D. Weiskopf, R. da Silva Antunes, S. Crotty, , A. Sette

This study shows that SARS-CoV-2 vaccines induce T cell responses that cross-recognize variants from Alpha to Omicron, with high preservation of CD4+ and CD8+ T cell epitopes.

bioRxiv · Dec 28, 2021 · PreprintImmunology

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes

C. H. Coelho, W. K. Tang, M. Burkhardt, J. D. Galson, O. Muratova, N. Salinas, T. L. Alves e Silva, K. Reiter, N. MacDonald, V. Nguyen, M. Byrne-Steele, W. Pan, X. Hou, B. Brown, M. Eisenhower, , P. Duffy

The paper identifies a high-affinity human monoclonal antibody against Pfs230 that blocks oocyst formation in mosquitoes by targeting gamete surfaces.

bioRxiv · Sep 25, 2020 · PreprintImmunology