V. Nguyen

An shRNA screen in primary human beta cells identifies the serotonin 1F receptor as a negative regulator of survival during transplant

The paper identifies the serotonin 1F receptor as a negative regulator of human beta cell survival during transplant and demonstrates a small molecule antagonist that improves glycemia in islet transplants.

Design of parallel ????-sheet nanofibrils using Monte-Carlo search, coarse-grained simulations, and experimental testing

The paper designs 7-mer peptides that self-assemble into parallel β-sheets using computational screening, simulations, and experimental validation.

Dissecting Multiparametric Cerebral Hemodynamics using Integrated Ultrafast Ultrasound and Multispectral Photoacoustic Imaging

The paper introduces a multimodal imaging platform to measure multiple cerebral hemodynamic parameters with high spatiotemporal resolution and applies it to study brain responses to hypercapnia.

NUCLEOPORIN1 mediates proteasome-based degradation of ABI5 to regulate Arabidopsis seed germination

This study identifies NUP1's role in Arabidopsis seed germination by mediating proteasome-dependent degradation of ABI5.

A conserved graft formation process in Picea abies and Arabidopsis thaliana identifies the PAT gene family as central regulators of wound healing

Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells

This study identifies metabolic perturbations in PWB-derived iPSCs, showing upregulated glutathione and downregulated sphingolipid metabolism, which may contribute to laser resistance in PWB vasculature.

Supporting materials: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

This study generates iPSCs from PWB fibroblasts and differentiates them into ECs that recapitulate disease phenotypes, identifying dysregulated pathways and genes involved in vascular malformations.

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

The paper shows how non-coding variants affecting IL2RA enhancers alter T cell feedback circuits, leading to opposing autoimmune outcomes in mice.

Cancer associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy

This study identifies three CAF subtypes in skin cancers and shows their association with tumor malignancy and immune modulation.

Cryo-EM structure of the human cardiac myosin filament

This paper solves the cryo-EM structure of the human cardiac myosin filament, revealing the arrangement of myosin, cMyBP-C, and titin and their functional interactions.

A biophysical framework for double-drugging kinases

This study develops a biophysical framework to analyze double-drugging of kinases, revealing cooperative effects between orthosteric and allosteric inhibitors and providing structural insights.

Abnormal weather drives disease outbreaks in wild and agricultural plants

The paper shows how abnormal weather influences disease outbreaks in both wild and agricultural plants, finding that historical climate affects wild plants while warming increases agricultural disease risks.

The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

This study shows that the SARS-CoV-2 Spike protein causes long-term mitochondrial gene suppression, cardiac fibrosis, and reduced myocardial contractility in obese mice.

A hormone-activated mobile RNAi pathway defends plant stem cells from virus infection

The paper identifies a hormone-activated RNAi pathway in plants that protects stem cells from virus infection by amplifying antiviral RNAi responses.

Indolent primary cutaneous B-cell lymphomas resemble persistent antigen reactions without signs of dedifferentiation

This study uses single-cell RNA sequencing to compare indolent primary cutaneous B-cell lymphomas with other B-cell proliferations, finding they resemble persistent antigen reactions with germinal center features.

Subcellular distribution of PP1 isoforms in holoenzyme complexes

The paper maps PP1 isoform subcellular distribution through holoenzyme complexes using proteomic and biochemical methods, identifying c20orf27 as a novel regulatory protein and highlighting SDS22's role in PP1 localization.

The Spike protein of SARS-CoV-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: implication for a role of Nrf2

This study shows that the SARS-CoV-2 Spike protein disrupts lipid metabolism and autophagy, increasing lipotoxicity via ferroptosis, which can be mitigated by Nrf2 inhibition.

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance

This paper develops an anti-HLA-A2 CAR for Tregs to induce transplant tolerance, showing they target HLA-A2-expressing grafts and suppress immune rejection.

TNFa and IL-6 promote ex-vivo proliferation of lineage-committed human regulatory T cells

This study shows pro-inflammatory cytokines TNF and IL-6 enhance Treg proliferation without compromising their function or lineage identity.

Extinction in complex communities as driven by adaptive dynamics

This study provides analytical solutions to adaptive dynamics equations to predict extinction outcomes in complex communities without relying on computationally intensive simulations.

Combined knockout of Lrrk2 and Rab29 does not result in behavioral abnormalities in vivo

This study shows that double knockout of Lrrk2 and Rab29 in mice does not lead to significant behavioral or dopamine neuron loss, suggesting the pathway can be safely targeted therapeutically.

Spike Protein of SARS-CoV-2 Activates Macrophages and Contributes to Induction of Acute Lung Inflammations in Mice

This study shows that SARS-CoV-2 Spike protein activates macrophages and induces acute lung inflammation in mice.

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer

This study identifies VGLL1 as a driver of resistance to endocrine therapy in ER+ breast cancer and shows that targeting VGLL1/TEAD interaction can inhibit resistant cell growth.

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes

The paper identifies a high-affinity human monoclonal antibody against Pfs230 that blocks oocyst formation in mosquitoes by targeting gamete surfaces.

T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk

This study identifies two enhancers regulating IL2RA expression in T cells, showing how their cell-type-specific effects influence autoimmune diabetes risk.

An efficient root transformation system for recalcitrant Vicia sativa.

This study develops an efficient hairy root transformation system for common vetch to enable functional gene analysis.

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to graft-versus-leukemia

The paper investigates the evolutionary trajectories of chronic lymphocytic leukemia cells during resistance to graft-versus-leukemia, finding distinct genetic and epigenetic dynamics post-transplant compared to chemotherapy.

Common Vetch: a drought tolerant, high protein neglected leguminous crop with potential as a sustainable food source.

This paper highlights common vetch as a sustainable protein source and discusses the potential to eliminate a toxin using genome editing.

Theoretical guidelines for editing ecological communities

This paper theoretically explores how to manipulate ecological communities by modifying pairwise interactions to achieve desired composition or resilience, while considering experimental costs.

Multi-omic profiling of tyrosine kinase inhibitor-resistant K562 cells suggests metabolic reprogramming to promote cell survival

This study identifies metabolic reprogramming and novel markers in TKI-resistant CML cells through multi-omic profiling.