Author

J. D. Lane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. J. Perez-Pulido· 1 shared A. Rubio· 1 shared A. Sanz· 1 shared B. Castejon-Vega· 1 shared B. Fernandez Dominguez· 1 shared C. Martin.Ruiz· 1 shared D. Shoemark· 1 shared E. Alcocer-Gomez· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperCell Biology

A. J. Perez-Pulido

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3 papers

Recent·Most cited

L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation

B. Castejon-Vega, A. Rubio, A. J. Perez-Pulido, J. L. Quiles, J. D. Lane, B. Fernandez Dominguez, M. B. Cachon-Gonzalez, C. Martin.Ruiz, A. Sanz, T. M. Cox, E. Alcocer-Gomez, M. D. Cordero

This study shows L-arginine improves autophagy defects in GM2 gangliosidoses by restoring mTOR signaling and reducing lysosomal permeability in patient fibroblasts.

bioRxiv · May 28, 2021Cell Biology

The ATG5 Interactome Links Clathrin Vesicular Trafficking With The ATG8 Lipidation Machinery For Autophagosome Assembly

J. D. Lane, K. Baines

This study identifies proteins interacting with the ATG12[~]ATG5 conjugate, revealing its role in linking clathrin-mediated trafficking to autophagosome formation.

bioRxiv · Sep 13, 2019 · PreprintCell Biology

LIR-dependent LMX1A/LMX1B autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

J. D. Lane, N. Jimenez-Moreno, P. Stathakos, Z. Anton, D. Shoemark, R. Sessions, R. Witzgall, M. Caldwell

This study shows LMX1A and LMX1B regulate autophagy in human midbrain dopaminergic neurons through LIR interactions, affecting mitochondrial function and resilience to rotenone toxicity.

bioRxiv · May 14, 2019 · PreprintCell Biology