L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation
B. Castejon-Vega, A. Rubio, A. J. Perez-Pulido, J. L. Quiles, J. D. Lane, B. Fernandez Dominguez, M. B. Cachon-Gonzalez, C. Martin.Ruiz, A. Sanz, T. M. Cox, E. Alcocer-Gomez, M. D. Cordero
This study shows L-arginine improves autophagy defects in GM2 gangliosidoses by restoring mTOR signaling and reducing lysosomal permeability in patient fibroblasts.
bioRxiv · May 28, 2021Cell Biology