M. D. Cordero

Inflammasome Profiling in Human Natural Killer Cells under Pro-inflammatory Stimuli and Solid Organ Transplantation

This study shows human NK cells can activate inflammasomes in vitro and in transplant patients, with distinct responses in CD56 subsets and sustained activation in renal dysfunction and transplant rejection.

NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype

This study shows that NLRP1 inflammasome promotes senescence and SASP through GSDMD-dependent regulation of p16, p21, p53, and SASP expression.

NEK7 activates the NLRP1 Inflammasome

This study shows NEK7 activates NLRP1 inflammasome independently of NLRP3, affecting IL-1β maturation in Nek7-deficient cells.

L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation

This study shows L-arginine improves autophagy defects in GM2 gangliosidoses by restoring mTOR signaling and reducing lysosomal permeability in patient fibroblasts.

NLRP3 inflammasome inhibition rescues Hutchinson-Gilford Progeria cellular phenotype and extend longevity of an animal model

This study shows that inhibiting the NLRP3 inflammasome improves cellular phenotype and extends lifespan in HGPS animal models.

Inhibition of the NLRP3 inflammasome prevents ovarian aging

This study shows that inhibiting the NLRP3 inflammasome improves ovarian function and fertility in aging mice by enhancing AMH, autophagy, and reducing FSH and estradiol levels.