Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretion
C. H. Burns, B. Yau, A. Rodriguez, J. D. Triplett, D. Maslar, Y. S. An, R. E. N. van der Welle, R. G. Kossina, M. R. Fisher, G. W. Strout, P. O. Bayguinov, T. Veenendaal, D. Chitayat, J. A. J. Fitzpatrick, J. Klumperman, , C. S. Asensio
This study shows that VPS41 deletion in pancreatic beta-cells causes diabetes by impairing insulin secretory granule formation and secretion.
bioRxiv · Apr 25, 2020Physiology