Author

B. Yau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2 Pathology· 1

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Organism:mouse· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

M. A. Kebede· 5 shared G. J. Cooney· 2 shared M. Larance· 2 shared N. Turner· 2 shared A. E. Brandon· 1 shared A. J. Lay· 1 shared A. L. Coppage· 1 shared A. Rodriguez· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersCell Biology

M. A. Kebede

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5 papers

Recent·Most cited

Optimised proteomic analysis of insulin granules from MIN6 β-cells identifies Scamp3, a novel regulator of insulin secretion and content

N. Norris, B. Yau, C. Famularo, H. Thomas, M. Larance, A. Senior, M. A. Kebede

This study identifies 211 proteins associated with insulin secretory granules in MIN6 β-cells, including SCAMP3, which regulates insulin storage and secretion.

bioRxiv · Apr 23, 2024Cell Biology

VPS41 deletion triggers progressive loss of insulin stores and downregulation of beta-cell identity

B. Yau, Y. An, M. Germanos, P. Schwarzkopf, G. van der Kraan, M. Larance, H. Webster, C. Burns, C. Asensio, M. A. Kebede

This study shows that VPS41 deletion causes insulin degradation and loss of beta-cell identity in mice, with lysosomal inhibition rescuing insulin content.

bioRxiv · Apr 17, 2024 · PreprintCell Biology

Insulin sensitivity is preserved in mice made obese by feeding a high starch diet

A. E. Brandon, L. Small, T.-V. Nguyen, E. Suryana, H. Gong, C. Yassmin, S. E. Hancock, T. Pulpitel, S. Stonehouse, L. Prescott, M. A. Kebede, B. Yau, L.-E. Quek, G. M. Kowalski, C. Bruce, , G. J. Cooney

This study shows that mice fed a high starch diet become obese but remain insulin sensitive, unlike those on a high fat diet, with differences in ceramide levels and lipogenesis contributing to this effect.

bioRxiv · May 25, 2022Physiology

Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretion

C. H. Burns, B. Yau, A. Rodriguez, J. D. Triplett, D. Maslar, Y. S. An, R. E. N. van der Welle, R. G. Kossina, M. R. Fisher, G. W. Strout, P. O. Bayguinov, T. Veenendaal, D. Chitayat, J. A. J. Fitzpatrick, J. Klumperman, , C. S. Asensio

This study shows that VPS41 deletion in pancreatic beta-cells causes diabetes by impairing insulin secretory granule formation and secretion.

bioRxiv · Apr 25, 2020Physiology

Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese mice

S. Chowdhury, S. Song, H. E. Zhang, X. M. Wang, M. G. Gall, D. M.-T. Yu, A. J. Lay, M. S.-W. Xiang, K. A. Evans, S. Wetzel, Y. Liu, B. Yau, A. L. Coppage, L. Lo, R. A. Stokes, , M. D. Gorrell

This study shows that FAP deficiency in diet-induced obese mice reduces liver steatosis, insulin resistance, and glucose intolerance while increasing FGF-21 levels.

bioRxiv · Nov 4, 2018 · PreprintPathology