Author

C. S. Asensio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

B. Hummer· 2 shared D. Chitayat· 2 shared D. Maslar· 2 shared I. Topalidou· 2 shared J. Cattin-Ortola· 2 shared J. Klumperman· 2 shared M. Ailion· 2 shared R. E. N. van der Welle· 2 shared

Activity by Year

2019-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

B. Hummer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretion

C. H. Burns, B. Yau, A. Rodriguez, J. D. Triplett, D. Maslar, Y. S. An, R. E. N. van der Welle, R. G. Kossina, M. R. Fisher, G. W. Strout, P. O. Bayguinov, T. Veenendaal, D. Chitayat, J. A. J. Fitzpatrick, J. Klumperman, , C. S. Asensio

This study shows that VPS41 deletion in pancreatic beta-cells causes diabetes by impairing insulin secretory granule formation and secretion.

bioRxiv · Apr 25, 2020Physiology

VPS41 recessive mutation causes ataxia and dystonia with retinal dystrophy and mental retardation by inhibiting HOPS function and mTORC1 signaling

R. E. N. van der Welle, R. Jobling, C. Burns, P. Sanza, C. ten Brink, A. Fasano, L. Chen, F. J. Zwartkruis, S. Zwakenberg, E. F. Griffin, J. van der Beek, T. Veenendaal, N. Liv, S. Blaser, C. Sepulveda, , J. Klumperman

This paper identifies VPS41 mutations causing neurodegenerative disease by disrupting HOPS function and mTORC1 signaling, leading to lysosomal dysfunction and impaired autophagy.

bioRxiv · Dec 18, 2019 · PreprintCell Biology

CCDC186 controls dense-core vesicle cargo sorting by exit

J. Cattin-Ortola, I. Topalidou, H.-T. Lau, B. Hummer, C. S. Asensio, S.-E. Ong, M. Ailion

This study identifies CCDC186 as a regulator of DCV cargo sorting by exit, showing its role in retaining mature DCV cargos and removing non-DCV cargos post-TGN.

bioRxiv · Nov 6, 2019 · PreprintCell Biology

EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulinoma cells

I. Topalidou, J. Cattin-Ortola, B. Hummer, C. S. Asensio, M. Ailion

This study investigates the role of EIPR1 in insulinoma cells, showing it controls DCV cargo retention and EARP complex localization, with effects on insulin secretion and cargo accumulation.

bioRxiv · Nov 6, 2019Cell Biology

Differential sorting behavior for soluble and transmembrane cargoes at the trans-Golgi network in endocrine cells.

B. H. Hummer, D. Maslar, M. Soltero Gutierrez, N. F. de Leeuw, C. S. Asensio

The paper quantifies TGN budding kinetics of constitutive and regulated secretory cargoes and reveals that transmembrane cargoes exit the TGN into non-regulated vesicles before incorporation into secretory granules.

bioRxiv · Oct 8, 2019Cell Biology