J. de Ridder

Mutational synergy with CREBBP loss in lymphomagenesis identified through forward insertional mutagenesis in a new DLBCL mouse model

Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway

This study shows that LKB1 loss in intestinal cells leads to a pre-malignant state linked to serrated colorectal cancer, which is amplified by loss-of-heterozygosity.

Accurate detection of circulating tumor DNA using nanopore consensus sequencing

This paper introduces CyclomicsSeq, a nanopore sequencing method that improves ctDNA detection sensitivity, enabling accurate TP53 mutation detection at 0.02% frequency in head-and-neck cancer patients.

Molecular Heterogeneity and Early Metastatic Clone Selection in Testicular Germ Cell Cancer Development

This study analyzes molecular heterogeneity in testicular germ cell cancer to understand tumor progression and metastasis.

A deep learning system can accurately classify primary and metastatic cancers based on patterns of passenger mutations

This paper develops a deep learning classifier using whole genome sequencing data to distinguish cancer types and identify metastatic origins.