Author

B. J. P. Huntly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

G. Giotopoulos· 3 shared G. S. Vassiliou· 3 shared A. Mupo· 2 shared D. Sasca· 2 shared G. Vassiliou· 2 shared H. Yun· 2 shared K. Tzelepis· 2 shared M. Gozdecka· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

G. Giotopoulos

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia

S. Agrawal Singh, J. Bagri, G. Giotopoulos, D. Azazi, S. J. Horton, J. W. Houghton, S. Anand, A. S. Bach, F. Stedham, R. Antrobus, G. Vassiliou, D. Sasca, H. Yun, A. Whetton, B. J. P. Huntly

This study identifies a repressive HOXA9-SAFB complex in AML that maintains disease by inhibiting differentiation and apoptosis, suggesting therapeutic targets.

bioRxiv · Oct 12, 2022 · PreprintCancer Biology

Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death.

K. Woodley, L. S. Dillingh, G. Giotopoulos, P. Madrigal, K. M. Rattigan, C. Philippe, V. Dembitz, A. S. M. Magee, R. Asby, L. N. van de Lagemaat, C. Mappereley, S. C. James, J. H. Prehn, K. Tzelepis, K. Rouault-Pierre, , P. Gallipoli

This study shows that inhibiting mannose metabolism sensitizes AML cells to cytarabine and FLT3 inhibitors by promoting ferroptotic cell death through fatty acid metabolism changes.

bioRxiv · May 16, 2022Cancer Biology

KAT7 is a therapeutic vulnerability of MLL-rearranged acute myeloid leukemia

Y. Z. Au, M. Gu, E. De Braekeleer, J. S. L. Yu, S. H. Ong, M. Gozdecka, X. Chen, K. Tzelepis, B. J. P. Huntly, G. S. Vassiliou, K. Yusa

This study identifies KAT7 as a critical therapeutic target in MLL-rearranged AML by showing its role in maintaining acetylation marks and supporting cell proliferation.

bioRxiv · Apr 25, 2020 · PreprintCancer Biology

Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimensional DNA topology to alter gene expression during leukemia induction

H. Yun, S. Vohra, A. Mupo, G. Giotopoulos, D. Sasca, S. J. Horton, S. Agrawal-Singh, E. Meduri, F. Basheer, L. Marando, M. Gozdecka, O. M. Dovey, A. Castillo-Venzor, X. Wang, P. Gallipoli, , B. J. P. Huntly

The paper investigates how mutations synergize to alter chromatin accessibility, enhancer landscapes, and 3D DNA topology in leukemia induction using a murine model.

bioRxiv · Mar 20, 2020Cancer Biology

Genetic modification of primary human B cells generates translationally-relevant models of high-grade lymphoma

R. Caeser, M. Di Re, J. A. Krupka, J. Gao, M. Lara-Chica, J. M. L. Dias, S. L. Cooke, R. Fenner, Z. Usheva, H. Runge, P. A. Beer, H. Eldaly, H.-K. Pak, C.-S. Park, G. Vassiliou, , D. J. Hodson

This study generates synthetic lymphoma models by genetically modifying primary human B cells to investigate oncogenic mutations in DLBCL.

bioRxiv · Apr 26, 2019 · PreprintCancer Biology