Author

J. Dockterman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

J. Coers· 3 shared G. Wallace· 2 shared A. Haldar· 1 shared A. J. Olive· 1 shared A. Piro· 1 shared C. M. Sassetti· 1 shared C. M. Smith· 1 shared E. M. Heckenberg· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

J. Coers

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Differential requirement for IRGM proteins during tuberculosis infection in mice

K. M. Wilburn, R. K. Meade, E. M. Heckenberg, J. Dockterman, J. Coers, C. M. Sassetti, A. J. Olive, C. M. Smith

This study shows that Irgm1 is critical for host defense against Mtb, but Irgm3 compensates for its loss, and combined loss of all three Irgm genes leads to worse outcomes in mice infected with Mtb.

bioRxiv · Nov 9, 2022Microbiology

Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection

J. Dockterman, J. I. Everitt, G. Wallace, J. Coers

This paper shows that Irgm proteins in mice reduce inflammation and scarring during Chlamydia infection without affecting bacterial levels, highlighting their role in disease tolerance.

bioRxiv · Jul 6, 2022 · PreprintImmunology

Dynamin-related Irgm proteins modulate LPS-induced caspase-4 activation and septic shock

R. Finethy, J. Dockterman, M. Kutsch, N. Orench-Rivera, G. Wallace, A. Piro, S. Luoma, A. Haldar, S. Hwang, J. Martinez, M. Kuehn, G. Taylor, J. Coers

This study identifies Irgm proteins as negative regulators of caspase-4 activation in response to LPS, showing their role in preventing septic shock.

bioRxiv · Mar 18, 2020Immunology