Author

K. M. Wilburn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

B. C. VanderVen· 2 shared C. R. Montague· 2 shared A. J. Olive· 1 shared A. K. Woods· 1 shared B. Qin· 1 shared C. M. Sassetti· 1 shared C. M. Smith· 1 shared C. W. McNamara· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

B. C. VanderVen

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Author profile →

3 papers

Recent·Most cited

Differential requirement for IRGM proteins during tuberculosis infection in mice

K. M. Wilburn, R. K. Meade, E. M. Heckenberg, J. Dockterman, J. Coers, C. M. Sassetti, A. J. Olive, C. M. Smith

This study shows that Irgm1 is critical for host defense against Mtb, but Irgm3 compensates for its loss, and combined loss of all three Irgm genes leads to worse outcomes in mice infected with Mtb.

bioRxiv · Nov 9, 2022Microbiology

Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis

K. M. Wilburn, C. R. Montague, B. Qin, A. K. Woods, M. S. Love, C. W. McNamara, P. G. Schultz, T. L. Southard, L. Huang, H. M. Petrassi, B. C. VanderVen

This paper identifies a small molecule agonist of Mtb adenylyl cyclase Rv1625c that inhibits cholesterol utilization and disrupts Mtb pathogenesis in mice.

bioRxiv · Aug 3, 2021Microbiology

Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis

B. C. VanderVen, E. V. Nazarova, C. R. Montague, T. La, K. M. Wilburn, N. Sukumar, W. Lee, S. Caldwell, D. G. Russell

This study identifies LucA as a coordinator of cholesterol and fatty acid uptake in Mtb, linking these processes to bacterial virulence.

bioRxiv · Mar 29, 2017Microbiology