Author

M. Kuehn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Physiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. L. Hessel· 3 shared W. A. Linke· 3 shared W. Ma· 3 shared C. Esoda· 2 shared D. Nissen· 2 shared T. C. Irving· 2 shared A. Haldar· 1 shared A. Piro· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersPhysiology

A. L. Hessel

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.

A. L. Hessel, M. Kuehn, S.-W. Han, W. Ma, T. C. Irving, B. A. Momb, T. Song, S. Sadayappan, W. A. Linke, B. M. Palmer

This study investigates the effects of MyBP-C knockout in skeletal muscle, finding altered length-dependent activation and myofilament structure, with implications for MyBP-C-related diseases.

bioRxiv · Oct 19, 2023 · PreprintPhysiology

Myosin-binding protein C forms C-links and stabilizes OFF states of myosin

A. L. Hessel, N. M. Engels, M. Kuehn, D. Nissen, R. L. Sadler, W. Ma, T. C. Irving, W. A. Linke, S. P. Harris

This study shows that MyBP-CC1C7 domains form C-links and stabilize myosin OFF states, affecting crossbridge kinetics and sarcomere function.

bioRxiv · Sep 10, 2023 · PreprintPhysiology

The distinctive mechanical and structural signatures of residual force enhancement in myofibers

A. L. Hessel, M. Kuehn, B. Palmer, D. Nissen, D. Mishra, V. Joumaa, J. Freundt, W. Ma, K. Nishikawa, T. Irving, W. A. Linke

The paper investigates titin's role in residual force enhancement (RFE) in muscle by analyzing structural changes in myofibers with and without titin cleavage and in a mutant strain.

bioRxiv · Feb 19, 2023 · PreprintPhysiology

Protective Plant Immune Responses are Elicited by Bacterial Outer Membrane Vesicles

H. M. McMillan, S. G. Zebell, J. B. Ristaino, X. Dong, M. Kuehn

This study shows that bacterial outer membrane vesicles from pathogenic and beneficial Pseudomonas species activate plant immune responses, offering protection against pathogens and revealing distinct mechanisms of action.

bioRxiv · Jul 24, 2020Microbiology

Dynamin-related Irgm proteins modulate LPS-induced caspase-4 activation and septic shock

R. Finethy, J. Dockterman, M. Kutsch, N. Orench-Rivera, G. Wallace, A. Piro, S. Luoma, A. Haldar, S. Hwang, J. Martinez, M. Kuehn, G. Taylor, J. Coers

This study identifies Irgm proteins as negative regulators of caspase-4 activation in response to LPS, showing their role in preventing septic shock.

bioRxiv · Mar 18, 2020Immunology

Pseudomonas aeruginosa leucine aminopeptidase influences early biofilm composition and structure via vesicle-associated anti-biofilm activity

C. Esoda, M. Kuehn

This paper shows that PaAP, a leucine aminopeptidase in P. aeruginosa, influences biofilm structure via its association with outer membrane vesicles, altering matrix composition and promoting biofilm detachment.

bioRxiv · Sep 27, 2019Microbiology

Vesicle-associated Pseudomonas aeruginosa leucine aminopeptidase modulates bacterial biofilms grown on host cellular substrates

C. Esoda, M. Kuehn

This study shows that PaAP, a leucine aminopeptidase in Pseudomonas aeruginosa, associated with outer membrane vesicles, inhibits biofilm formation and disperses biofilm microcolonies of other pathogens.

bioRxiv · Mar 24, 2019 · PreprintMicrobiology