Author

J. E. Chaft

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. A. Jungbluth· 1 shared A. Chow· 1 shared A. D. Jayaprakash· 1 shared A. J. Plodkowski· 1 shared A. Quintanal-Villalonga· 1 shared A. T. Satpathy· 1 shared B. Houck-Loomis· 1 shared C. M. Lovly· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. A. Jungbluth

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Author profile →

2 papers

Recent·Most cited

Regional and clonal T cell dynamics at single cell resolution in immune checkpoint blockade

J. A. Pai, A. Chow, J. Sauter, M. Mattar, H. Rizvi, H. J. Woo, N. Shah, F. Uddin, A. Quintanal-Villalonga, J. M. Chan, P. Manoj, V. Allaj, M. Baine, J. E. Chaft, A. J. Plodkowski, , M. D. Hellmann

This study uses scTCR/RNA-seq to analyze T cell dynamics in lung cancer patients before and after ICB, finding regional heterogeneity and clonal persistence associated with clinical responses.

bioRxiv · Sep 27, 2021 · PreprintImmunology

YES1 amplification: a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics

P.-D. Fan, G. Narzisi, A. D. Jayaprakash, E. Venturini, N. Robine, P. Smibert, S. Germer, H. A. Yu, E. J. Jordan, P. K. Paik, Y. Y. Janjigian, J. E. Chaft, L. Wang, A. A. Jungbluth, S. Middha, , M. Ladanyi

This study identifies YES1 amplification as a novel mechanism of resistance to EGFR inhibitors in lung cancer using transposon mutagenesis and clinical genomic analysis.

bioRxiv · Mar 17, 2018Cancer Biology