A. T. Satpathy

Convergent Epigenetic Evolution Drives Relapse in Acute Myeloid Leukemia

This study identifies convergent epigenetic evolution in AML relapse using ATAC-seq and mtscATAC, showing that epigenetic changes drive relapse independent of genetic mutations.

The temporal progression of immune remodeling during metastasis.

This paper uses longitudinal scRNA-seq to study immune changes in lung metastasis, identifying inflammatory programs and signaling networks associated with metastatic progression.

Inosine Induces Stemness Features in CAR T cells and Enhances Potency

This study shows that inosine enhances CAR T cell stemness and function by modulating metabolism and epigenetics, leading to improved anti-tumor potency.

Enhanced Effector Activity of Mediator Kinase Module Deficient CAR-T Cells

This study identifies the Mediator kinase module as a regulator of T cell differentiation and shows that its inhibition enhances effector T cell potency.

Latent human herpesvirus 6 is reactivated in chimeric antigen receptor T cells

The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.

A unique epigenomic landscape defines CD8+ tissue-resident memory T cells

This study identifies distinct epigenetic trajectories in CD8+ T cells during acute infection, revealing how chromatin accessibility changes guide the development of tissue-resident memory T cells versus circulating memory T cells.

Microbiota-instructed regulatory T cell differentiation is mediated by a distinct RORγt+ antigen presenting cell subset

This study identifies a distinct RORγt+ antigen presenting cell subset that mediates microbiota-driven regulatory T cell differentiation, revealing a mechanism for maintaining immune tolerance.

Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Populations with Unique Homology to Thymic Epithelium

This paper identifies two extrathymic Aire-expressing cell types with transcriptional and genomic similarities to thymic epithelium and shows their role in immune tolerance.

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

This study investigates the interaction between macrophages and exhausted CD8+ T cells in the tumor microenvironment, showing they form a feedback loop that promotes tumor survival.

Regional and clonal T cell dynamics at single cell resolution in immune checkpoint blockade

This study uses scTCR/RNA-seq to analyze T cell dynamics in lung cancer patients before and after ICB, finding regional heterogeneity and clonal persistence associated with clinical responses.

BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen

Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state

This study shows that macrophage inflammatory and regenerative responses are phase-dependent on the cell cycle, with S-G2/M phases linked to tissue remodeling and reduced IFNG-induced repolarization.

Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection

This study identifies 309 host proteins interacting with SARS-CoV-2 RNA during infection and reveals their roles in virus-induced cell death and mitochondrial dysfunction.

Latent Plasticity of Effector-like Exhausted CD8 T cells contributes to memory responses

The paper identifies a subset of exhausted CD8 T cells with plasticity to reprogram into memory cells, suggesting new targets for immunotherapy.

Transient "rest" induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

This study shows that temporarily stopping CAR-T cell signaling can reverse exhaustion and improve their anti-tumor function through transcriptional and epigenetic changes.

Clonal replacement of tumor-specific T cells following PD-1 blockade

This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.