Chromosomally unstable tumor cells specifically require KIF18A for proliferation
C. Marquis, C. L. Fonseca, K. A. Queen, L. Wood, S. E. Vandal, H. L. Malaby, J. E. Clayton, J. Stumpff
This study shows KIF18A is essential for proliferation of chromosomally unstable tumor cells but not near-diploid cells, with effects linked to centrosome fragmentation and mitotic defects.
bioRxiv · Jun 18, 2020Cell Biology