Author

K. A. Queen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Stumpff· 3 shared A. Cario· 1 shared C. L. Berger· 1 shared C. L. Fonseca· 1 shared C. Marquis· 1 shared F. Aswad· 1 shared H. L. Malaby· 1 shared J. E. Clayton· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

J. Stumpff

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells

K. Schutt, K. A. Queen, K. Fisher, O. Budington, W. Mao, W. Liu, Y. Xiao, F. Aswad, J. Joseph, J. Stumpff

This study identifies the KIF18A alpha-4 helix as a therapeutic target, showing that mutations or inhibitors targeting this region disrupt proliferation of chromosomally unstable tumor cells.

bioRxiv · Oct 16, 2023 · PreprintCancer Biology

Modification of the Neck Linker of KIF18A Alters Microtubule Subpopulation Preference

K. A. Queen, A. Cario, C. L. Berger, J. Stumpff

This study shows that a phosphomimetic mutation in KIF18A's neck-linker alters its localization to microtubule subpopulations, affecting mitotic spindle positioning and progression.

bioRxiv · May 2, 2023Cell Biology

Chromosomally unstable tumor cells specifically require KIF18A for proliferation

C. Marquis, C. L. Fonseca, K. A. Queen, L. Wood, S. E. Vandal, H. L. Malaby, J. E. Clayton, J. Stumpff

This study shows KIF18A is essential for proliferation of chromosomally unstable tumor cells but not near-diploid cells, with effects linked to centrosome fragmentation and mitotic defects.

bioRxiv · Jun 18, 2020Cell Biology