J. Stumpff

Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells

This study identifies the KIF18A alpha-4 helix as a therapeutic target, showing that mutations or inhibitors targeting this region disrupt proliferation of chromosomally unstable tumor cells.

Modification of the Neck Linker of KIF18A Alters Microtubule Subpopulation Preference

This study shows that a phosphomimetic mutation in KIF18A's neck-linker alters its localization to microtubule subpopulations, affecting mitotic spindle positioning and progression.

The histone H3.3 K27M mutation found in diffuse midline gliomas coordinately disrupts adjacent H3.3 Ser31 phosphorylation and the fidelity of chromosome segregation

This paper shows that the H3.3 K27M mutation in gliomas reduces Ser31 phosphorylation, leading to chromosome missegregation and tumor formation.

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

This study shows that pathogenic KIF22 mutations disrupt anaphase chromosome segregation, leading to cell proliferation issues and cytokinesis failure.

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding

This study determines the structural mechanism by which KIFBP remodels kinesin motors to block microtubule-binding, revealing a 2-pronged inhibition strategy.

Micronuclei arising due to loss of KIF18A form stable micronuclear envelopes and do not promote tumorigenesis

This study shows that micronuclei formed due to KIF18A loss form stable envelopes and do not promote tumorigenesis, challenging the idea that all micronuclei contribute to cancer.

Chromosomally unstable tumor cells specifically require KIF18A for proliferation

This study shows KIF18A is essential for proliferation of chromosomally unstable tumor cells but not near-diploid cells, with effects linked to centrosome fragmentation and mitotic defects.

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint

This study identifies aneuploid cancer cells as more vulnerable to spindle assembly checkpoint (SAC) inhibition and explores the underlying mechanisms.

The Kinesin-5 Tail Domain Directly Modulates the Mechanochemical Cycle of the Motor for Anti-Parallel Microtubule Sliding

This study shows the kinesin-5 tail domain regulates motor activity by modulating ATP hydrolysis and microtubule sliding, leading to slow motility and force generation.

Kinesin-Binding Protein (KBP) buffers the activity of Kif18A and Kif15 in mitosis to ensure accurate chromosome segregation

This study identifies KBP as a regulator of KIF18A and KIF15 during mitosis, showing it buffers their activity to ensure accurate chromosome segregation.

The Human Kinesin Kif18A’s Neck Linker Permits Navigation of Microtubule Bound Obstacles within the Mitotic Spindle

This study shows that the long neck linker of Kif18A enables it to navigate microtubule-associated protein obstacles to accumulate at K-fiber plus-ends during mitosis.

Mitotic chromosome alignment is required for proper nuclear envelope reassembly

This study shows that mitotic chromosome alignment is necessary for correct nuclear envelope reassembly and cell proliferation, despite being dispensable for maintaining euploidy.