Islet macrophages shift to a reparative state following pancreatic beta-cell death and are a major source of islet IGF-1
D. Nackiewicz, M. Dan, M. Speck, S. Chow, Y.-C. Chen, J. A. Pospisilik, B. Verchere, J. Ehses
This study shows that islet macrophages transition to a reparative state after beta-cell death, producing IGF-1 and supporting insulin secretion.
bioRxiv · Nov 15, 2019Immunology