Author

M. Speck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

M. K. Levings· 3 shared M. Mojibian· 3 shared M. Haque· 2 shared V. Fung· 2 shared A. J. Lam· 1 shared B. Verchere· 1 shared C. M. Wardell· 1 shared D. Boardman· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

M. K. Levings

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Integration of exogenous and endogenous co-stimulatory signals by CAR-Tregs

I. Rosado-Sanchez, M. Haque, K. Salim, M. Speck, V. Fung, D. Boardman, M. Mojibian, G. Raimondi, M. K. Levings

This study compares CAR-Treg function with different co-stimulatory domains, finding in vivo equivalence between CARs with and without CD28 despite in vitro differences.

bioRxiv · Nov 10, 2022 · PreprintImmunology

PTEN is required for human Treg suppression of costimulation

A. J. Lam, M. Haque, K. A. Ward-Hartstonge, P. Uday, C. M. Wardell, J. K. Gillies, M. Speck, M. Mojibian, R. I. K. Geltink, M. K. Levings

This study shows PTEN is not essential for general Treg function but is required for their ability to suppress costimulatory molecule expression by antigen-presenting cells.

bioRxiv · Mar 6, 2022 · PreprintImmunology

Islet macrophages shift to a reparative state following pancreatic beta-cell death and are a major source of islet IGF-1

D. Nackiewicz, M. Dan, M. Speck, S. Chow, Y.-C. Chen, J. A. Pospisilik, B. Verchere, J. Ehses

This study shows that islet macrophages transition to a reparative state after beta-cell death, producing IGF-1 and supporting insulin secretion.

bioRxiv · Nov 15, 2019Immunology

Functional effects of chimeric antigen receptor co-receptor signaling domains in human Tregs

N. A. Dawson, I. Rosado Sanchez, G. Novakovsky, V. Fung, Q. Huang, E. McIver, G. Sun, J. Gillies, M. Speck, P. C. Orban, M. Mojibian, M. K. Levings

This study compares ten CAR signaling domains in Tregs, finding that wild-type CD28 CARs are most effective in suppressing graft-versus-host disease.

bioRxiv · Aug 29, 2019Immunology