Author

J. A. Pospisilik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

E. Dror· 3 shared I. Panzeri· 3 shared L. Fagnocchi· 3 shared S. Apostle· 3 shared A. Drougard· 2 shared V. Wegert· 2 shared A. Bergsma· 1 shared A. Bremser· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

E. Dror

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Developmental priming of cancer susceptibility

I. Panzeri, L. Fagnocchi, S. Apostle, M. Tompkins, E. Wolfrum, Z. Madaj, G. Hostetter, Y. Liu, K. Schaefer, C.-H. Yang, A. Bergsma, A. Drougard, E. Dror, PERMUTE, D. Chandler, , J. A. Pospisilik

The paper shows that early life epigenetic variation can prime cancer-susceptibility states that persist into adulthood and correlate with poor prognosis in human cancers.

Nature Cancer · Jan 24, 2025Peer-reviewedCancer Biology

An acute microglial metabolic response controls metabolism and improves memory

A. Drougard, E. H. Ma, V. Wegert, R. Sheldon, I. Panzeri, N. Vatsa, S. Apostle, L. Fagnocchi, J. Schaf, K. Gossens, J. Völker, S. Pang, A. Bremser, E. Dror, F. Giacona, , J. A. Pospisilik

The paper identifies an acute microglial metabolic response to high-fat diet that improves metabolism and memory by converting harmful fatty acids into beneficial metabolites.

bioRxiv · Apr 3, 2023Physiology

Identification of two β-cell subtypes by 7 independent criteria

E. Dror, L. Fagnocchi, V. Wegert, S. Apostle, B. Grimaldi, T. Gruber, I. Panzeri, S. Heyne, K. D. Hoeffler, V. Kreiner, R. Ching, T. T.-H. Lu, A. Semwal, B. Johnson, P. Senapati, , J. A. Pospisilik

The paper identifies two distinct β-cell subtypes, βHI and βLO, using seven independent criteria and shows that H3K27me3 dosage regulates their ratio in vivo.

bioRxiv · Jan 31, 2023Cell Biology

Resident T cells orchestrate adipose tissue remodeling in a site peripheral to infection

A. M. Kabat, A. Hackl, D. E. Sanin, P. Zeis, K. M. Grzes, F. Baixauli, R. Kyle, G. Caputa, J. Edwards-Hicks, M. Villa, N. Rana, J. D. Curtis, A. Castoldi, J. Cupovic, L. Dreesen, , E. J. Pearce

The paper shows that Th2 lymphocytes in mesenteric adipose tissue interact with stromal cells to influence adiposity during helminth infection.

bioRxiv · Feb 24, 2022 · PreprintImmunology

Islet macrophages shift to a reparative state following pancreatic beta-cell death and are a major source of islet IGF-1

D. Nackiewicz, M. Dan, M. Speck, S. Chow, Y.-C. Chen, J. A. Pospisilik, B. Verchere, J. Ehses

This study shows that islet macrophages transition to a reparative state after beta-cell death, producing IGF-1 and supporting insulin secretion.

bioRxiv · Nov 15, 2019Immunology