J. F. Ayroles

Sex differences in immune function and disease risk are not easily explained by an evolutionary mismatch

This study examines sex differences in immune function and disease risk across populations, finding no consistent support for the evolutionary mismatch hypothesis.

Adaptations to water stress and pastoralism in the Turkana of northwest Kenya

The paper identifies genetic regions associated with adaptation to water stress and pastoralism in the Turkana people using genome sequencing.

Relative abundance data can misrepresent heritability of the microbiome

This paper shows that using relative abundance data to estimate microbiome heritability can lead to imprecise, overestimated, and biased results due to taxon interdependencies, large sample sizes, and microbial co-abundances.

Diet unmasks genetic variants that regulate lifespan in outbred Drosophila

This study identifies lifespan-altering genetic variants in Drosophila under different diets, showing context-dependent effects and genotype-by-environment interactions.

Host evolutionary history and ecological context modulate the adaptive potential of the microbiome

This study shows that host genotype, microbiome, and environment interact to influence host fitness, with mismatches causing fitness costs in a high-sugar diet.

When the microbiome defines the host phenotype: selection on vertical transmission in varying environments

The paper shows that intermediate vertical microbiome transmission can be adaptive in fluctuating environments by increasing phenotypic variability in offspring.

Meta-analysis suggests the microbiome responds to Evolve and Resequence experiments in Drosophila melanogaster

The paper re-analyzes genomic data from Drosophila melanogaster E&R experiments to show the microbiome responds to host selection, with bacterial diversity changes linked to host traits.