Author

J. Faraldo-Gomez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Approach:statistical model· 4 Approach:deep learning· 3 Assay:cryo-EM· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

H. Mchaourab· 2 shared J. L. Robertson· 2 shared N. Bernhardt· 2 shared R. Chadda· 2 shared R. Stix· 2 shared T. N. Ozturk· 2 shared A. Banerjee· 1 shared A. Forsythe· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

H. Mchaourab

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7 papers

Recent·Most cited

Mitigation of membrane morphology defects explain stability and orientational specificity of CLC dimers

T. N. Ozturk, N. Bernhardt, N. Schwartz, R. Chadda, J. L. Robertson, J. Faraldo-Gomez

This study shows that CLC-ec1 dimers stabilize by eliminating a membrane defect, using simulations and experiments to support this mechanism.

bioRxiv · Mar 16, 2023 · PreprintBiophysics

Structure of the Shaker Kv channel and mechanism of slow C-type inactivation

X.-F. Tan, C. Bae, R. Stix, A. I. Fernandez-Marino, K. Huffer, T.-H. Chang, J. Jiang, J. Faraldo-Gomez, K. J. Swartz

The paper determines the structure of the Shaker Kv channel and reveals that slow C-type inactivation involves dilation of the selectivity filter.

bioRxiv · Sep 21, 2021 · PreprintBiophysics

Cryo-EM structure of an elusive pre-transport intermediate of the multidrug transporter BmrCD reveals modes of asymmetric drug binding

T. M. Thaker, S. Mishra, W. Zhou, J. Faraldo-Gomez, H. Mchaourab, T. M. Tomasiak

Cryo-EM and EPR analysis reveal cooperative substrate binding in BmrCD in an architecture primed for transport.

bioRxiv · Mar 13, 2021 · PreprintBiophysics

Force-correction Analysis Method for Derivation of Multidimensional Free Energy Landscapes from Adaptively Biased Replica Simulations

F. Marinelli, J. Faraldo-Gomez

This paper introduces FCAM, a method to calculate multidimensional free-energy landscapes from biased molecular dynamics simulations, showing it outperforms existing methods in accuracy and convergence.

bioRxiv · Feb 17, 2021Biophysics

Dimerization of a membrane transporter is driven by differential energetics of lipid solvation of dissociated and associated states

R. Chadda, N. Bernhardt, E. G. Kelley, S. C. M. Teixeira, K. Griffith, A. Gil-Ley, T. N. Ozturk, L. E. Hughes, A. Forsythe, V. Krishnamani, J. Faraldo-Gomez, J. L. Robertson

bioRxiv · Oct 5, 2020Biophysics

DHHC20 palmitoyl-transferase reshapes the membrane to foster catalysis

R. Stix, J. Song, A. Banerjee, J. Faraldo-Gomez

This paper investigates how DHHC20 reshapes membranes to facilitate catalysis through biochemical and computational methods.

Biophysical Journal · Feb 1, 2020Peer-reviewedBiophysics

Confidence Analysis of DEER Data and its Structural Interpretation with Ensemble-Biased Metadynamics

E. J. Hustedt, F. Martinelli, R. A. Stein, J. Faraldo-Gomez, H. Mchaourab

The paper develops methods to assess confidence in DEER data and improves structural interpretation using uncertainty-aware molecular simulations.

bioRxiv · Jul 10, 2018Biophysics