Author

K. J. Swartz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Ballesteros· 2 shared A. I. Fernandez-Marino· 2 shared A. Jara-Oseguera· 2 shared C. Bae· 2 shared A. Aleksandrova· 1 shared A. Gochman· 1 shared A. J. Paquette· 1 shared B. Wang· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersPhysiology

A. Ballesteros

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Author profile →

6 papers

Recent·Most cited

Cannabidiol sensitizes TRPV2 channels to activation by 2-APB

A. Gochman, X. Tan, C. Bae, H. Chen, K. J. Swartz, A. Jara-Oseguera

This study shows that cannabidiol (CBD) significantly enhances TRPV2 channel activation by 2-APB but not by heat, revealing multiple CBD binding sites and mechanisms.

bioRxiv · Jan 27, 2023Biophysics

Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators

P. Selvakumar, A. I. Fernandez-Marino, N. Khanra, C. He, A. J. Paquette, B. Wang, R. Huang, V. V. Smider, W. J. Rice, K. J. Swartz, J. R. Meyerson

This study determines the structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators, revealing two distinct mechanisms to suppress channel activity.

bioRxiv · Apr 19, 2022Biophysics

Structure of the Shaker Kv channel and mechanism of slow C-type inactivation

X.-F. Tan, C. Bae, R. Stix, A. I. Fernandez-Marino, K. Huffer, T.-H. Chang, J. Jiang, J. Faraldo-Gomez, K. J. Swartz

The paper determines the structure of the Shaker Kv channel and reveals that slow C-type inactivation involves dilation of the selectivity filter.

bioRxiv · Sep 21, 2021 · PreprintBiophysics

Expression of a membrane-targeted fluorescent reporter disrupts auditory hair cell mechanoelectrical transduction and causes profound deafness.

A. Ballesteros, T. S. Fitzgerald, K. J. Swartz

This study shows that high expression of a membrane-targeted fluorescent reporter in mice disrupts auditory hair cell function and causes deafness.

bioRxiv · Sep 18, 2020Physiology

Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms

K. E. Huffer, A. Aleksandrova, A. Jara-Oseguera, L. R. Forrest, K. J. Swartz

The paper aligns TRP channel transmembrane domains to identify conserved structural features and functional mechanisms.

bioRxiv · May 14, 2020Biophysics

Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

A. Ballesteros, C. Fenollar-Ferrer, K. J. Swartz

The paper models TMC1 using TMEM16 structures, identifies a cavity near the lipid interface, and shows dextran permeability requires TMC1/2 and functional MET channels.

bioRxiv · May 21, 2018Biophysics