J. Frunzke

Expanding the phage galaxy: Isolation and characterization of five novel Streptomyces siphoviruses Ankus, Byblos, DekoNeimoidia, Mandalore, and Naboo

The paper isolates and characterizes five novel Streptomyces siphoviruses, expanding phage diversity and contributing to understanding phage-host interactions in Streptomyces.

Decoupling the molecular versatility of aminoglycosides via drug or target modification enables community-wide antiphage defense

This study uncouples antiphage and antibacterial properties of aminoglycosides through resistance mechanisms, demonstrating community-wide antiphage defense in bacterial co-cultures.

Isolation and characterization of the new Streptomyces phages Kamino, Geonosis, Abafar and Scarif infecting a broad range of host species

The paper isolates and characterizes four new Streptomyces phages with varying host ranges and temperate/virulent properties, expanding the available phage resources for studying antiviral strategies in Streptomyces.

Seed coating with phages for sustainable plant biocontrol of plant pathogens and influence of the seed coat mucilage

This study demonstrates that phages can bind to seed coat mucilage and enhance plant seedling survival against pathogens, suggesting phage-based biocontrol as a sustainable strategy.

Aminoglycoside antibiotics inhibit phage infection by blocking an early step of the phage infection cycle

This study shows aminoglycosides inhibit phage infection by blocking an early step in the viral life cycle, with implications for bacterial community protection.

Genome sequencing of the bacteriophage CL31 and interaction with the host strain Corynebacterium glutamicum ATCC 13032

This study sequenced the bacteriophage CL31 and analyzed its interaction with Corynebacterium glutamicum, revealing genomic features and infection dynamics.

Identification of Gip as a novel phage-encoded gyrase inhibitor protein featuring a broad activity profile

This study identifies Gip, a phage-encoded protein that inhibits gyrase across multiple bacterial species, suggesting potential for drug development targeting DNA gyrase.

Genome sequence and characterization of five bacteriophages infecting Streptomyces coelicolor and Streptomyces venezuelae: Alderaan, Coruscant, Dagobah, Endor1 and Endor2

The paper isolates and characterizes five new Streptomyces phages, revealing their morphology, lifestyle, and genetic diversity.

Deciphering the rules underlying xenogeneic silencing and counter-silencing of Lsr2-like proteins

This study investigates how Lsr2-like proteins silence and counter-silence horizontally acquired genomic regions in actinobacteria, revealing binding preferences and demonstrating synthetic counter-silencing strategies.

The impact of CO2/HCO3- availability on anaplerotic flux in PDHC-deficient Corynebacterium glutamicum strains

This study investigates how changes in intracellular CO2/HCO3- levels affect growth and anaplerotic flux in a PDHC-deficient Corynebacterium glutamicum strain, showing that increasing CO2/HCO3- levels can restore growth.

The MarR-type regulator MalR is involved in stress-responsive cell envelope remodeling in Corynebacterium glutamicum

This study identifies MalR as a regulator of stress-responsive cell envelope remodeling in C. glutamicum through genome-wide binding analysis and transcriptome profiling.