A. Hardy

Decoupling the molecular versatility of aminoglycosides via drug or target modification enables community-wide antiphage defense

This study uncouples antiphage and antibacterial properties of aminoglycosides through resistance mechanisms, demonstrating community-wide antiphage defense in bacterial co-cultures.

Timing and magnitude of the type-I interferon response are determinants of disease tolerance in arbovirus infection

This study shows that the timing and magnitude of the type-I interferon response determine disease tolerance in bluetongue virus infection between sheep and cattle.

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito

This paper identifies a mutation in the E2 glycoprotein of Mayaro virus that enhances transmission in Aedes aegypti but reduces replication in human cells, suggesting a trade-off in host adaptation.

Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen

The paper identifies DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen, showing it limits viral replication independently of SUMOylation.

Aminoglycoside antibiotics inhibit phage infection by blocking an early step of the phage infection cycle

This study shows aminoglycosides inhibit phage infection by blocking an early step in the viral life cycle, with implications for bacterial community protection.

Multilamellar mesoporous silica nanoparticles using a cationic co-surfactant dual-templating method.

This paper synthesizes and characterizes multilamellar mesoporous silica nanoparticles using a cationic co-surfactant templating method, showing that layer number affects drug adsorption and release.

Genome sequencing of the bacteriophage CL31 and interaction with the host strain Corynebacterium glutamicum ATCC 13032

This study sequenced the bacteriophage CL31 and analyzed its interaction with Corynebacterium glutamicum, revealing genomic features and infection dynamics.

Genome sequence and characterization of five bacteriophages infecting Streptomyces coelicolor and Streptomyces venezuelae: Alderaan, Coruscant, Dagobah, Endor1 and Endor2

The paper isolates and characterizes five new Streptomyces phages, revealing their morphology, lifestyle, and genetic diversity.