Author

J. G. Caldwell

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Biochemistry· 1

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Lu· 1 shared J. E. Elias· 1 shared J. L. Shumate· 1 shared L. Zhang· 1 shared N. Elghobashi-Meinhardt· 1 shared N. Olsson· 1 shared P. Saha· 1 shared S. R. Pfeffer· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

A. Lu

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1 paper

Recent·Most cited

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

P. Saha, J. L. Shumate, J. G. Caldwell, N. Elghobashi-Meinhardt, A. Lu, L. Zhang, N. Olsson, J. E. Elias, S. R. Pfeffer

The paper investigates the role of inter-domain dynamics in cholesterol transport by NPC1 and NPC1L1 proteins, showing that domain movement is essential and that Ezetimibe inhibits NPC1L1 by binding to multiple domains.

bioRxiv · Mar 26, 2020Biochemistry