Author

N. Elghobashi-Meinhardt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Organism:virus· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Lu· 1 shared A. Pisliakov· 1 shared C. Wang· 1 shared D. Berta· 1 shared E. Frezza· 1 shared E. Rosta· 1 shared G. Wells· 1 shared J. E. Elias· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Lu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintJan 7, 2022

Covariant Fitness Clusters Reveal Structural Evolution of SARS-CoV-2 Polymerase Across the Human Population

C. Wang, N. Elghobashi-Meinhardt, W. E. Balch

The paper uses Gaussian process regression to analyze SARS-CoV-2 RdRp mutations, identifying fitness clusters that evolve during the pandemic and contribute to viral spread.

DOI 10.1101/2022.01.07.475295

virusproteomics

𝕏 PostBluesky

BiochemistrybioRxivNov 3, 2020

Modelling the active SARS-CoV-2 helicase complex as a basis for structure-based inhibitor design

D. Berta, M. Badaoui, P. J. Buigues…·E. Rosta

This study models the active SARS-CoV-2 helicase complex to provide structural insights for inhibitor design.

DOI 10.1039/d1sc02775a

virusprotein structure

𝕏 PostBluesky

BiochemistrybioRxivMar 26, 2020

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

P. Saha, J. L. Shumate, J. G. Caldwell…·S. R. Pfeffer

The paper investigates the role of inter-domain dynamics in cholesterol transport by NPC1 and NPC1L1 proteins, showing that domain movement is essential and that Ezetimibe inhibits NPC1L1 by binding to multiple domains.

DOI 10.7554/elife.57089

experimental assayhost-pathogen & immune response

𝕏 PostBluesky