Author

J. G. Wise

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Approach:mechanistic / dynamical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

C. Park· 2 shared J. W. McCormick· 2 shared L. Ammerman· 2 shared P. D. Vogel· 2 shared C. A. Follit· 1 shared G. Chen· 1 shared L. A. McCormick· 1 shared S. B. Mertz· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

C. Park

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Computationally accelerated identification of P-glycoprotein inhibitors

L. A. McCormick, J. W. McCormick, C. Park, C. A. Follit, J. G. Wise, P. D. Vogel

This study identifies nine novel P-gp inhibitors using a computationally accelerated drug discovery pipeline, showing they reverse multidrug resistance in cancer cells with minimal toxicity to non-cancerous cells.

bioRxiv · Mar 5, 2024 · PreprintCancer Biology

Transport Dynamics of MtrD: an RND multidrug efflux pump from Neisseria gonorrhoeae

L. Ammerman, S. B. Mertz, C. Park, J. G. Wise

This study uses molecular dynamics simulations to analyze how MtrD transports Azithromycin and rejects Streptomycin, revealing peristaltic motions and potential multiple transport pathways.

bioRxiv · Feb 24, 2021Biochemistry

Transport of Alzheimer's Associated Amyloid-β Catalyzed by P-glycoprotein

J. W. McCormick, L. Ammerman, G. Chen, P. D. Vogel, J. G. Wise

This study shows P-glycoprotein actively transports amyloid-β proteins, suggesting a role in Alzheimer's disease progression.

bioRxiv · Oct 22, 2020Biochemistry