Computationally accelerated identification of P-glycoprotein inhibitors
L. A. McCormick, J. W. McCormick, C. Park, C. A. Follit, J. G. Wise, P. D. Vogel
This study identifies nine novel P-gp inhibitors using a computationally accelerated drug discovery pipeline, showing they reverse multidrug resistance in cancer cells with minimal toxicity to non-cancerous cells.
bioRxiv · Mar 5, 2024 · PreprintCancer Biology