J. Gautrot

Hybrid cancer stem cells utilise vascular tracks for collective streaming invasion in a metastasis-on-a-chip device

This study shows hybrid cancer stem cells use vascular tracks for collective invasion in a metastasis-on-a-chip model of oral squamous cell carcinoma.

Engineered Protein Nanosheets for the Scale up of Mesenchymal Stem Cell Culture on Bioemulsions

This paper develops engineered protein nanosheets to stabilize bioemulsions for scalable mesenchymal stem cell culture, showing 100-fold expansion and matrix deposition.

Matrix Nanoscale Mechanics Regulates Exosome Production by Mesenchymal Stem Cells

This study shows that matrix nanoscale mechanics regulate exosome production by mesenchymal stem cells using bioemulsions as microcarriers, increasing exosome output by 100%.

Biomimetic Artificial Bone Marrow Niches for the Scale Up of Hematopoietic Stem Cells

This paper develops biomimetic bone marrow niches using bioemulsions to expand hematopoietic stem cells in a scalable format.

Strong Elastic Protein Nanosheets Enable the Culture and Differentiation of Induced Pluripotent Stem Cells on Microdroplets

This study shows that elastic protein nanosheets on microdroplets support iPSC adhesion, expansion, and differentiation into cardiomyocytes by modulating interfacial mechanics.

Vascularised Cardiac Spheroids-on-a-Chip for Testing the Toxicity of Therapeutics

This paper develops vascularised cardiac spheroids-on-a-chip to test therapeutic toxicity, showing improved functionality and toxicity detection compared to suspended spheroids.

Engineering of Co-Surfactant-Free Bioactive Protein Nanosheets for the Stabilisation of Bioemulsions Enabling Adherent Cell Expansion

This paper designs co-surfactant-free protein nanosheets for bioemulsions that support cell adhesion and proliferation, demonstrating their potential for scalable cell manufacturing.

Supercharged Protein Nanosheets for Cell Expansion on Bioemulsions

This study shows supercharged proteins can form elastic nanosheets that support cell adhesion and ECM protein adsorption, enabling stem cell expansion on bioemulsions.

Impact of Pericytes on the Stabilisation of Microvascular Networks in Microfluidic Systems in Response to Nanotoxicity

This study shows pericytes stabilize microvascular networks in microfluidic systems, protect against stress and nanotoxicity, and improve in vitro model reliability.

Design of an Integrated Microvascularised Human Skin-on-a-Chip Tissue Equivalent Model

This paper designs a microvascularised human skin-on-a-chip model and shows that vascularization improves epidermal stratification and differentiation in vitro.