J. Connelly

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

Engineered human myogenic cells in hydrogels generate functional myofibers within dystrophic mouse muscle

This study shows engineered human myogenic cells in hydrogels form functional myofibers in dystrophic mouse muscle, producing dystrophin and integrating with host nerves and blood vessels.

Insight into the emerging insect to human pathogen Photorhabdus revealing geographic differences in immune cell tropism.

This study compares the pathogenic activities of Photorhabdus asymbiotica isolates from different geographic regions, showing geographic differences in immune cell tropism and temperature-dependent infectivity.

Design of an Integrated Microvascularised Human Skin-on-a-Chip Tissue Equivalent Model

This paper designs a microvascularised human skin-on-a-chip model and shows that vascularization improves epidermal stratification and differentiation in vitro.

Toll-like receptor 2 orchestrates a potent anti-tumor response in non-small cell lung cancer

This study identifies TLR2 as a tumor suppressor in early-stage lung cancer, showing its role in immune surveillance and tumor growth reduction through synthetic agonist administration.

Distinct genetic pathways define pre-leukemic and compensatory clonal hematopoiesis in Shwachman-Diamond syndrome

The paper identifies distinct genetic pathways in Shwachman-Diamond syndrome that lead to pre-leukemic and compensatory clonal hematopoiesis through EIF6 and TP53 mutations.