J. Goncalves

The maintenance of centriole appendages and motile cilia basal body anchoring relies on TBCCD1

This study identifies TBCCD1 as essential for centriole appendage assembly and maintenance, and for anchoring motile cilia basal bodies, with implications for ciliopathy networks.

Amino acids 484 and 494 of SARS-CoV-2 spike are hotspots of immune evasion affecting antibody but not ACE2 binding

Long-term single-cell passaging of human iPSC fully supports pluripotency and high-efficient trilineage differentiation capacity

This study validates a long-term single-cell passaging method for human iPSC that maintains pluripotency and efficient trilineage differentiation.

Differential effects of day-night cues and the circadian clock on the barley transcriptome

The paper examines how day-night cues and the circadian clock influence the barley transcriptome, finding that day-night cues can restore transcript oscillations in clock mutants.

LUZP1 and the tumour suppressor EPLIN are negative regulators of primary cilia formation

This study identifies LUZP1 and EPLIN as negative regulators of primary cilia formation by modulating actin dynamics at the centrosome and basal body.

Development of Triazoles based on AZT and their Anti-Viral Activity Against HIV-1

The paper develops triazole-based AZT derivatives and shows they reduce HIV-1 infection, with two compounds nearly clearing it in a pre-exposure prophylaxis model.