S. J. Davis

An Arabidopsis leaf expression atlas across diurnal and developmental scales

The paper combines single-cell RNA-seq and bulk time-series data to create an Arabidopsis leaf expression atlas showing cell-type-specific gene expression changes over time.

Single-plant-omics reveals the cascade of transcriptional changes during the vegetative-to-reproductive transition

This study uses single-plant-transcriptomics to uncover the transcriptional cascade during the vegetative-to-reproductive transition in Arabidopsis thaliana, revealing both binary and continuous developmental processes.

Complex epistatic interactions between ELF3, PRR9, and PRR7 regulates the circadian clock and plant physiology

The paper investigates the genetic interactions between ELF3, PRR9, and PRR7 in Arabidopsis, revealing complex epistatic relationships affecting circadian rhythms and plant development.

High-density volumetric super-resolution microscopy

This paper introduces SMLFM, a volumetric super-resolution microscopy technique that achieves higher speed and accuracy in detecting single molecules in live cells.

POLCAM: Instant molecular orientation microscopy for the life sciences

POLCAM provides a fast, simplified method for single-molecule orientation microscopy using polarization cameras, enabling rapid molecular anisotropy analysis in biological samples.

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency

The paper evaluates TcE formats to determine how contact distance and flexibility affect their potency in forming immunological synapses.

resPAINT: Accelerating volumetric super-resolution localisation microscopy by active control of probe emission

The paper introduces resPAINT, a method that enhances volumetric super-resolution microscopy by actively controlling probe emission, achieving up to 50-fold faster localisation rates without sacrificing contrast.

A Non-Canonical Function of Arabidopsis ERECTA Proteins in Gibberellin Signaling

This paper shows that Arabidopsis ERECTA proteins interact with SWI3B to regulate GID1 gene transcription, linking them to gibberellin signaling.

HLA-E restricted, HIV-1 suppressing, Gag specific CD8+ T cells offer universal vaccine opportunities

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

vLUME: 3D Virtual Reality for Single-molecule Localization Microscopy

vLUME is a VR software for visualizing 3D SMLM data, enabling segmentation and quantification of fluorescence puncta with high fidelity.

Differential effects of day-night cues and the circadian clock on the barley transcriptome

The paper examines how day-night cues and the circadian clock influence the barley transcriptome, finding that day-night cues can restore transcript oscillations in clock mutants.

Photoperiod sensing of the circadian clock is controlled by ELF3 and GI

This study shows ELF3 and GI are essential for circadian clock-mediated photoperiod sensing in Arabidopsis.

The costs of close contact: Visualizing the energy landscape of cell contacts at the nanoscale

This paper uses quantum dots to study how protein size affects diffusion and entry into cell contacts, revealing size-dependent exclusion and reduced diffusion in dense adhesion protein regions.

A cell-topography based mechanism for ligand discrimination by the T-cell receptor

This paper develops a model showing T-cell receptors discriminate ligands based on dwell-time in phosphatase-depleted contacts constrained by cell topography, predicting signaling potency without multi-step proof-reading.

Hydrodynamic trapping measures the interaction between membrane-associated molecules

The paper introduces hydrodynamic trapping to measure membrane protein interaction potentials and shows how protein shape, glycosylation, and flexibility affect their behavior.

Reconstitution of immune cell interactions in free-standing membranes

The paper presents an in vitro system using synthetic vesicles to study spatiotemporal aspects of immune synapse formation and signaling molecule distribution in T cells.

The stoichiometric signature of Rhodopsin-family G protein coupled receptors

The paper analyzes 71 GPCRs from a single cell to show that Rhodopsin-family receptors predominantly exist as monomers rather than dimers.