Author

J. Grembecka

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

J. L. Merchant· 1 shared S. Duan· 1 shared S. Sheriff· 1 shared S. Sundaresan· 1 shared T. Cierpicki· 1 shared T. W. Sawyer· 1 shared U. B. Elvis-Offiah· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

J. L. Merchant

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1 paper

Recent·Most cited

Clinically defined mutations in MEN1 alter its tumor-suppressive function through increased menin turnover

S. Duan, S. Sheriff, U. B. Elvis-Offiah, T. W. Sawyer, S. Sundaresan, T. Cierpicki, J. Grembecka, J. L. Merchant

This study shows that specific MEN1 mutations destabilize menin, reducing its tumor-suppressive function and leading to neuroendocrine tumor development.

bioRxiv · Dec 20, 2022 · PreprintCancer Biology