S. Duan

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

Single-cell transcriptomics reveals cellular hierarchies and aberrant CTS contraction-mediated premature hair regression in androgenetic alopecia

This study uses single-cell transcriptomics to identify cellular hierarchies and CTS contraction as a driver of premature hair regression in AGA, showing ML-7 can improve hair growth.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Recruitment of FBXO22 for Targeted Degradation of NSD2

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

Spatial profiling of neuro-immune interactions in gastroenteropancreatic NETs

This study uses spatial protein profiling to identify tissue-specific neuro-immune signatures in GEP-NETs, showing that duodenal gastrinomas express immune and pro-inflammatory factors that influence neuroendocrine traits.

Combined multiphoton microscopy and somatostatin receptor type 2 imaging of pancreatic neuroendocrine tumors

This study combines somatostatin receptor imaging and multiphoton microscopy to improve the localization of pancreatic neuroendocrine tumors.

Clinically defined mutations in MEN1 alter its tumor-suppressive function through increased menin turnover

This study shows that specific MEN1 mutations destabilize menin, reducing its tumor-suppressive function and leading to neuroendocrine tumor development.

Design, fabrication, and preclinical testing of a miniaturized, multispectral, chip-on-tip, imaging probe for intraluminal fluorescence imaging of the gastrointestinal tract

This paper designs and tests a miniaturized fluorescence imaging probe for detecting gastrointestinal tumors using exogenous contrast agents.

Quantitative Characterization of Duodenal Gastrinoma Autofluorescence Using Multi-Photon Microscopy

This study uses multiphoton microscopy to distinguish duodenal gastrinomas from normal tissue using autofluorescence and SHG signals, achieving high classification accuracy.

GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming

This study shows that inactivating Men1 in glial cells leads to neuroendocrine differentiation and tumorigenesis, exploiting glial plasticity.

The PNUTS-PAD domain recruits MYC to the PNUTS:PP1 phosphatase complex via the oncogenic MYC-MB0 region

This paper identifies the MB0 region of MYC as a direct binder to the PNUTS amino-terminal domain (PAD), revealing a molecular mechanism for MYC regulation by the PNUTS:PP1 phosphatase complex.

Tropomyosin in mugwort cross-reacts to house dust mite, eliciting non-Th2 response in allergic rhinitis patients sensitized to house dust mite

The paper investigates cross-reactivity between mugwort and house dust mite allergens, finding that mugwort tropomyosin induces a non-Th2 response in allergic rhinitis patients.

Extracellular Vesicle-Mediated Purinergic Signaling Contributes to Host Microenvironment Plasticity and Metastasis in Triple Negative Breast Cancer

This study shows that extracellular vesicle-associated NDPK-B promotes metastasis in triple-negative breast cancer by modulating purinergic signaling and the host microenvironment.

Dynamic metabolic reprogramming in dendritic cells: an early response to influenza infection that is essential for effector function

This paper identifies dynamic metabolic reprogramming in dendritic cells during influenza infection, showing it is essential for effector function and immune response initiation.

Lesions of canine prostate underwent laser ablation, radiofrequency ablation, and microwave ablation: Lesions shapes and clinical significances

This study compares the shapes and sizes of prostate lesions in dogs treated with laser, radiofrequency, and microwave ablation, finding significant differences in lesion morphology and volume.

GLUT1 inhibition blocks growth of RB1-positive Triple Negative Breast Cancer

This study shows that GLUT1 inhibition reduces growth of RB1-positive TNBC cells with high glycolytic activity and low OXPHOS, suggesting a therapeutic target in this subset.

A Chemical Toolbox for the Study of Bromodomains and Epigenetic Signaling

The paper presents a set of 25 chemical probes targeting human bromodomains and demonstrates their utility in studying muscle cell differentiation and triple negative breast cancer.