S. Sundaresan

Molecular Dynamics Trajectory Analysis of Permeation (MDTAP): A tool to analyze permeation events across membrane proteins

MDTAP automates the analysis of permeation events across membrane proteins and nucleic acids from MD trajectories, providing visualization and insights into solute/solvent transport mechanisms.

Clinically defined mutations in MEN1 alter its tumor-suppressive function through increased menin turnover

This study shows that specific MEN1 mutations destabilize menin, reducing its tumor-suppressive function and leading to neuroendocrine tumor development.

Menin-MLL Inhibitor MI-503 Blocks Menin Nuclear Export and Suppresses Hypergastrinemia

This study shows that MI-503 inhibits gastrin gene expression by blocking Menin nuclear export in gastrinomas.