Author

T. Cierpicki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. K. Mapp· 1 shared A. Mapp· 1 shared B. M. Linhares· 1 shared B. S. Morgan· 1 shared C. A. Fierke· 1 shared C. S. Regan· 1 shared E. Martinez Valdivia· 1 shared J. Grembecka· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

A. K. Mapp

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A lipopeptidomimetic of transcriptional activation domains selectively disrupts Med25 PPIs

O. N. Pattelli, E. Martinez Valdivia, M. S. Beyersdorf, C. S. Regan, M. Rivas, S. D. Merajver, T. Cierpicki, A. K. Mapp

The paper develops a lipopeptidomimetic that selectively disrupts Med25 protein-protein interactions, showing improved affinity and selectivity for Med25 over other coactivators.

bioRxiv · Mar 24, 2023 · PreprintBiochemistry

Clinically defined mutations in MEN1 alter its tumor-suppressive function through increased menin turnover

S. Duan, S. Sheriff, U. B. Elvis-Offiah, T. W. Sawyer, S. Sundaresan, T. Cierpicki, J. Grembecka, J. L. Merchant

This study shows that specific MEN1 mutations destabilize menin, reducing its tumor-suppressive function and leading to neuroendocrine tumor development.

bioRxiv · Dec 20, 2022 · PreprintCancer Biology

Unexpected Specificity within Dynamic Transcriptional Protein-Protein Complexes

M. J. Henley, B. M. Linhares, B. S. Morgan, C. A. Fierke, T. Cierpicki, A. Mapp

The paper investigates the molecular recognition of disordered activators by coactivators, revealing that specific contacts and coactivator plasticity drive specificity despite apparent nonspecific interactions.

bioRxiv · May 29, 2020Biochemistry