Using Human Induced Pluripotent Stem Cell Derived Organoids to Identify New Pathologies in Patients with PDX1 Mutations
Mansa Krishnamurthy, Daniel O. Kechele, Taylor R. Broda, Xinghao Zhang, Jacob R. Enriquez, Heather A. McCauley, J. Guillermo Sanchez, Kyle W. McCracken, Joseph Palermo, Anas Bernieh, Margaret H. Collins, Inas H. Thomas, Haley C. Neef, Amer Heider, Andrew Nahum Dauber, James M. Wells
This study uses patient-derived organoids to identify new pathologies in individuals with PDX1 mutations, revealing intestinal and gastric metaplasia.
bioRxiv · Apr 25, 2021 · PreprintDevelopmental Biology