Kyle W. McCracken

This study uses single-cell RNA sequencing in rhesus macaques to identify transitional states and signaling shifts in nephron progenitor cells during late gestation, suggesting a mechanism for lateral branch nephrogenesis.

This paper uses optogenetic control of RET signaling to induce controlled budding in human kidney organoids.

This study identifies the roles of canonical and non-canonical Wnt signaling pathways in directing epithelial tubule interconnection during zebrafish kidney regeneration.

This paper introduces VID scaffolds to enhance diffusion in neural organoids, improving their function and drug response compared to conventional organoids.

This paper introduces a human kidney epithelial microphysiological platform (Epi-MAP) to model collecting duct physiology from stem cells, enabling advanced functional analysis and drug testing.

This paper describes a method to integrate collecting systems in kidney organoids by fusing distal nephron with ureteric bud tissues, enabling functional nephrons with continuous epithelial lumens.

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

This study uses patient-derived organoids to identify new pathologies in individuals with PDX1 mutations, revealing intestinal and gastric metaplasia.