Heather A. McCauley

Enteroendocrine Cells Regulate Intestinal Barrier Permeability

This study shows enteroendocrine cells are essential for maintaining intestinal barrier integrity and that their secreted hormones PYY and octreotide can restore barrier function in inflammatory conditions.

Human organoid modeling of congenital malformations caused by RFX6 mutations reveal an essential role for this transcription factor in establishing and maintaining duodenal identity upstream of PDX1

This study uses human organoids to show RFX6 mutations cause duodenal malformations by disrupting PDX1 and other signaling pathways.

Ontogeny and function of the circadian clock in intestinal organoids

This study investigates circadian rhythms in human intestinal organoids, showing circadian phase-dependent necrotic cell death responses to TcdB and identifying anti-phasic gene expression between mouse and human enteroids.

Using Human Induced Pluripotent Stem Cell Derived Organoids to Identify New Pathologies in Patients with PDX1 Mutations

This study uses patient-derived organoids to identify new pathologies in individuals with PDX1 mutations, revealing intestinal and gastric metaplasia.