J. Morris

Silencing of a raspberry homologue of VRN1 is associated with disruption of dormancy induction and misregulation of subsets of dormancy-associated genes.

This study identifies a VRN1 homologue in raspberry that, when silenced by upstream insertions in Glen Dee, causes dormancy misregulation and altered gene expression.

Marine phytoplankton and heterotrophic bacteria rapidly adapt to future pCO2 conditions in experimental co-cultures

This study shows marine phytoplankton and heterotrophic bacteria adapt to future CO2 levels in co-cultures, with cyanobacteria showing increased growth and Alteromonas evolving metabolic shifts.

Host lipids regulate multicellular behavior of a predator of a human pathogen

The paper identifies a host-derived phosphatidylcholine that induces multicellular aggregation in Capsaspora owczarzaki, suggesting a link between host physiology and symbiont behavior.

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection

This paper shows that enolase inhibitors, specifically HEX, are effective against Naegleria fowleri by inhibiting its glycolytic pathway and extending survival in infected rodents.

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

This study shows that reducing CERS1 in skeletal muscle worsens age-related muscle dysfunction in mice and humans, linking it to inflammation and fibrosis.

Extensive variation in germline de novo mutations in Poecilia reticulata

This study quantifies de novo mutations in guppies, finding substantial individual and family variation in germline mutation rates and evidence of shared mutations across siblings.

Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

The paper links mitochondrial ceramide, CoQ, and the respiratory chain in a pathway driving insulin resistance in skeletal muscle, showing protective effects of reducing ceramide or supplementing CoQ.

Defining composition and function of the rhizosphere microbiota of barley genotypes exposed to growth-limiting nitrogen supplies

This study investigates how nitrogen availability affects the composition and function of the rhizosphere microbiota in barley genotypes, showing host genetic control over microbial communities under nitrogen-limiting conditions.

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer's Disease

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

LARP1 regulates metabolism and mTORC1 activity in cancer

This study identifies LARP1 as a key regulator of metabolism and mTORC1 activity in cancer, showing its role in sustaining cellular metabolism and driving cancer progression.

PERK-ATAD3A interaction protects mitochondrial proteins synthesis during ER stress

The paper identifies ATAD3A as a PERK interactor that modulates PERK-eIF2 signaling during ER stress, allowing selective translation of mitochondrial proteins.

Heavy metal pollution impacts soil bacterial community structure and antimicrobial resistance at the Birmingham 35th Avenue Superfund Site

This study examines how heavy metal pollution affects soil bacterial communities and antimicrobial resistance at a Superfund site, finding reduced diversity and increased AMR gene prevalence in contaminated soils.

IDENTIFYING PLANT GENES SHAPING MICROBIOTA COMPOSITION IN THE BARLEY RHIZOSPHERE

The paper identifies plant genes influencing rhizosphere microbiota composition in barley using metagenomics and RNA-seq.

Microgravity effect on murine T cells exposed to suborbital flight aboard Blue Origins New Shepard vehicle

This study examines how brief microgravity exposure during a suborbital flight affects murine T cells, finding reduced functionality and differential sensitivity between CD4+ and CD8+ subsets.

Applications of the indole-alkaloid gramine modulate the assembly of individual members of the barley rhizosphere microbiota

This study investigates how exogenous gramine affects the barley rhizosphere microbiota, revealing its role in modulating microbial community assembly.

HIGH-RESOLUTION CHARACTERIZATION OF MALE ORNAMENTATION AND REEVALUATION OF SEX LINKAGE IN GUPPIES

This study reevaluates Y-linkage in guppy male ornamentation using automated image analysis, finding that individual ornaments are not predominantly Y-linked but modifier loci affecting overall coloration may be.

Divergence and Remarkable Diversity of the Y Chromosome in Guppies

This study examines Y chromosome divergence and diversity in guppies, finding that recombination suppression occurs through gradual mechanisms rather than inversions, and that haplotype diversity is linked to female preference for rare color variations.

Restricted sequence variation in Streptococcus pyogenes penicillin binding proteins

The paper investigates PBP sequence variation in S. pyogenes and finds that mutations in PBPs are rare, with few amino acid differences across most isolates, contrasting with more frequent mutations in S. pneumococcus.

A high-throughput genomic screen identifies a role for the plasmid-borne Type II secretion system of Escherichia coli O157:H7 (Sakai) in plant-microbe interactions

A high-throughput genomic screen identifies the plasmid-borne Type II secretion system (T2SS) of E. coli O157:H7 as important for plant-microbe interactions, while a chaperone-usher fimbrial gene cluster is not.

Chitosan primes plant defence mechanisms against Botrytis cinerea, including expression of Avr9/Cf-9 rapidly-elicited genes

This study shows chitosan primes plant defense against Botrytis cinerea by enhancing gene expression and resistance in tomato and brassicaceous plants.

A footptrint of plant eco-geographic adaptation on the composition of the barley rhizosphere bacterial microbiota

This study shows that eco-geographical adaptation of barley influences its rhizosphere microbiota composition, with domesticated varieties showing stronger genotype effects than wild relatives.

Glutamine deprivation regulates the origin and function of cancer cell exosomes

This study shows that glutamine deprivation increases exosome release from cancer cells, which promote tumor growth and blood vessel networks through Rab11a-dependent mechanisms.

Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.

High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant reads

This paper introduces INVAR, a method to improve ctDNA detection sensitivity using patient-specific sequencing panels and variant read integration, achieving ppm-level detection in clinical samples.

Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours

The paper uses sequencing methods to show that cell-free tumour DNA levels are low in renal cancer but can still be informative with improved detection strategies.

4-oxo-2-nonenal Adducts In HDL Are Elevated In Familial Hypercholesterolemia: Identification Of Modified Sites And Functional Consequences

This study identifies elevated 4-oxo-2-nonenal (ONE) adducts in HDL from familial hypercholesterolemia patients and shows their functional impact on HDL function and macrophage responses.

Extreme heterogeneity in sex chromosome differentiation and dosage compensation in livebearers

The paper analyzes sex chromosome differentiation and dosage compensation in livebearing fish, finding extreme variation across species and a novel neo-sex chromosome in P. picta.

Glucose signaling is important for nutrient adaptation during differentiation of pleomorphic African trypanosomes

This study shows glucose depletion triggers differentiation in African trypanosomes, with glucose acting as both a metabolic substrate and signaling molecule.