Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor
Y. Xiang, J. Halin, Z. Fan, S. Hu, M. Wang, L. Qiu, Z. Zhang, P. Mattjus, Y. Zhang
This study identifies topovectorial mechanisms that control Nrf1 proteolytic processing to generate mature CNC-bZIP transcription factor isoforms through ER-associated degradation.
bioRxiv · Mar 27, 2018Biochemistry