L. Qiu

Deletion of Nrf1 exacerbates oxidative stress-induced cellular senescence by disrupting the cell homeostasis

This study shows that deleting Nrf1 increases oxidative stress-induced cellular senescence by disrupting homeostasis, as evidenced by increased senescence markers and impaired autophagy.

Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators

This study shows that reactive oxygen species (ROS) from IgG-opsonized targets suppress phagocyte surveillance by oxidizing cytoskeletal regulators, leading to cell compaction and podosome disassembly.

Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

Dual mechanism of kinetochore microtubule detachment

This paper investigates how kinetochore microtubules detach by combining experimental measurements and modeling, revealing a dual mechanism involving NDC80 complex binding energetics and microtubule catastrophe.

Optimizing anesthesia and delivery approaches for dosing into lungs of mice

This study compares pulmonary dosing efficiency in mice under different anesthetic and delivery methods, finding that ketamine/xylazine anesthesia and oropharyngeal aspiration improve lung delivery compared to isoflurane and intranasal dosing.

A point mutation in Chl biosynthesis gene Mg-chelatase I subunit influences on leaf color and metabolism in strawberry

This study identifies a point mutation in the CHLI gene of strawberry that affects leaf color and metabolism by reducing chlorophyll and flavonoid levels and altering light sensitivity.

Integrated single-nucleus and spatial transcriptomics captures transitional states in soybean nodule symbiosis establishment

The paper integrates single-nucleus and spatial transcriptomics to map transitional states in soybean nodule symbiosis, identifying functionally distinct cell subgroups and a transitional infected cell subtype.

Wound-like tumor periphery in human breast cancer predicts a convergent drug nonresponse

The paper identifies a wound-like tumor periphery in breast cancer as a uniparameter marker predicting multidrug nonresponse and poor prognosis across molecular subtypes.

The Food Additive Xanthan Gum Drives Adaptation of the Human Gut Microbiota

This study shows that xanthan gum, a common food additive, promotes the adaptation of the human gut microbiota by enabling a novel degradation pathway in an uncultured Ruminococcaceae bacterium and facilitating cross-feeding by Bacteroides species.

GmSALT3 expression improves reactive oxygen species detoxification in salt-stressed soybean roots

The paper uses RNA-seq to show that GmSALT3 improves ROS detoxification in salt-stressed soybean roots by enhancing antioxidant activity and related pathways.

TCF11 Has a Potent Tumor-Repressing Effect than Its Prototypic Nrf1α by Definition of both Similar yet Different Regulatory Profiles, with a Striking Disparity from Nrf2

The paper compares the tumor-repressing effects of TCF11 and Nrf1, showing TCF11 is more potent, while both have similar regulatory profiles distinct from Nrf2.

In-House Forecasting of Crop Latitude Adaptation through a Daylength-sensing-based Environment Adaptation Simulator (DEAS)

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

A two-stage ECG signal denoising method based on deep convolutional network

This paper proposes a two-stage deep learning method for ECG denoising using U-net and DR-net models, showing improved performance over single-stage methods.

Diverse genetic origins of medieval steppe nomad conquerors

The paper analyzes whole-genome sequences of Khazar elites to show their polyethnic origins and genetic admixture from conquered populations, with no persistent genetic traces in Europe.

Nrf1 is endowed with a dominant tumor-repressing effect onto the Wnt/β-Catenin-dependent and -independent signaling networks in the human liver cancer

This study shows Nrf1 represses tumor growth by inhibiting Wnt/β-catenin signaling and other pathways through ubiquitination of β-catenin and regulation of key genes.

Convergent eusocial evolution is based on a shared reproductive groundplan plus lineage-specific plastic genes

This study identifies shared and lineage-specific genes involved in eusociality by comparing transcriptomic profiles of pharaoh ants and honey bees.

Penton-dodecahedron of fowl adenovirus serotype 4 as a vaccine candidate for the control of related diseases

This study demonstrates that FAdV-4 penton-dodecahedron (Pt-Dd) and recombinant fiber-1 proteins induce strong immune responses and 100% protection against FAdV-4 in chickens, making them viable vaccine candidates.

Coordinative Metabolism of Glutamine Carbon and Nitrogen in proliferating Cancer Cells Under Hypoxia

The paper identifies a hypoxia-specific metabolic pathway in cancer cells that redirects glutamine nitrogen to secretory dihydroorotate, avoiding ammonia toxicity and supporting tumor growth.

Nrf1D is the first candidate secretory transcription factor in the blood plasma, with its precursor existing as a unique redox-sensitive transmembrane CNC-bZIP protein in somatic tissues

Molecular mechanisms controlling the multistage post-translational processing of endogenous Nrf1α/TCF11 proteins to yield distinct proteoforms within the coupled positive and negative feedback circuits

This study identifies the molecular mechanisms and post-translational modifications governing the generation of distinct Nrf1α/TCF11 proteoforms and their involvement in feedback circuits with regulatory proteins.

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

This study identifies topovectorial mechanisms that control Nrf1 proteolytic processing to generate mature CNC-bZIP transcription factor isoforms through ER-associated degradation.