Z. Fan

Structural and Dynamic Impacts of Single-atom Disruptions to Guide RNA Interactions within the Recognition Lobe of Geobacillus stearothermophilus Cas9

This study investigates how single-atom mutations in the recognition lobe of GeoCas9 affect its structure, dynamics, and guide RNA interactions without altering its functional specificity.

Agonism between family groups of cooperative breeding smooth-coated otters (Lutrogale perspicillata)

The paper analyzes agonistic interactions among smooth-coated otters using citizen science videos, finding that larger family groups have an advantage and environmental factors influence interaction intensity.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

Commensal microbiome dysbiosis elicits IL-8 signaling to drive fibrotic skin disease

The paper investigates the role of commensal microbiome dysbiosis in keloid fibrosis, finding elevated IL-8 signaling drives collagen accumulation and fibroblast migration.

Single cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1+ macrophage activation

This study uses single-cell RNA sequencing and spatial transcriptomics to characterize the muscle microenvironment in PAD, identifying altered endothelial diversity and LYVE1+ macrophage activation.

A maize lipid droplet-associated protein is modulated by a virus to promote viral multiplication and infection

This study shows that rice black streaked dwarf virus recruits a maize lipid droplet-associated protein to regulate fatty acid metabolism, promoting viral multiplication and infection.

The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions

This study shows that Apold1 is not essential for normal angiogenesis but is critical for revascularization under ischemic conditions and tumor growth.

Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins

The paper uses cryo-EM to analyze native doublet microtubules in Tetrahymena thermophila, identifying MIPs and showing their role in cilia function through CFAP77 knockout.

Distinct roles of Nrf1 and Nrf2 in monitoring the reductive stress response to dithiothreitol (DTT)

This paper investigates the distinct roles of Nrf1 and Nrf2 in the reductive stress response to DTT, showing differential regulation of redox and ER stress defense genes.

A CRISPR-based instant DNA repositioning system and the early intranuclear life of HSV-1

This paper introduces CRISPR-nuPin, a system to reposition viral DNA to the nuclear periphery, revealing how HSV-1 genome localization affects transcription and pathogenesis during early infection.

RNA decay defines the therapeutic response to transcriptional perturbation in leukaemia

The paper shows that mRNA decay rates determine the effectiveness of transcriptional inhibitors in leukemia, with short-lived mRNAs being more responsive and long-lived ones being modulated by RNA-binding proteins.

Dynamics of peripheral blood flow across sleep stages

This study compares pulse rate variability (PRV) and heart rate variability (HRV) across sleep stages using peripheral blood flow measurements, finding PRV provides similar information to HRV and may offer additional insights.

The connection between Rap1 and Talin1 in CD4+ T Lymphocytes

This study investigates the role of Rap1-talin1 interactions and RIAM in integrin activation in CD4+ T cells, showing that RIAM can substitute for Rap1 binding in some contexts.

Monitoring the effects of chemical stimuli on live cells with metasurface-enhanced infrared reflection spectroscopy

This study uses MEIRS to monitor live cell responses to chemical stimuli in real-time, detecting morphological, adhesive, lipid, and signaling changes.

Differential yet integral contributions of Nrf1 and Nrf2 in the human antioxidant cytoprotective response against tert-butylhydroquinone as a pro-oxidative stressor

This study investigates the differential and cooperative roles of Nrf1 and Nrf2 in regulating antioxidant gene expression and cytoprotective responses to tBHQ-induced oxidative stress in human cell lines.

Strawberry sweetness and consumer preference are enhanced by specific volatile compounds

This study identifies volatile compounds that enhance strawberry sweetness and consumer liking, showing their potential for breeding and quality control.

Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from COVID-19 virus

The paper determines the near-atomic structure of the SARS-CoV-2 polymerase complex and shows reduced activity and thermostability compared to SARS-CoV.

Out of the Qinghai-Tibetan Plateau and get flourishing - the evolution of Neodon voles (Rodentia: Cricetidae) revealed by systematic sampling and low coverage whole genome sequencing

This study identifies six new Neodon species using systematic sampling and low coverage whole genome sequencing, revealing the Qinghai-Tibetan Plateau as the origin and highlighting climate change and geographic isolation as drivers of speciation.

3′-UTR shortening contributes to subtype-specific cancer growth by breaking stable ceRNA crosstalk of housekeeping genes

This study identifies 3′-UTR shortening as a mechanism driving subtype-specific cancer growth by disrupting ceRNA networks involving housekeeping genes in breast cancer.

Bone marrow transplantation rescues monocyte recruitment defect and improves cystic fibrosis in mice

This study shows bone marrow transplantation improves survival and reduces inflammation in CFTRΔF508 mice by rescuing monocyte adhesion defects.

Effects of topical PaiTeLing in nude mice implanted with human condyloma acuminatum tissue infected with HPV 6, 31, and 81: comparison with imiquimod and interferon-α-2b

This study compares the effects of PaiTeLing, imiquimod, and interferon-α-2b on HPV-infected tissue in nude mice, finding enhanced immune responses with imiquimod and PaiTeLing.

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

This study identifies topovectorial mechanisms that control Nrf1 proteolytic processing to generate mature CNC-bZIP transcription factor isoforms through ER-associated degradation.

Exploring the mutational robustness of nucleic acidsby searching genotype neighbourhoods in sequencespace

The paper uses in silico SELEX to study mutational robustness of an L-Arm binding aptamer, finding two functional genotype neighborhoods with similar binding affinity to the wild-type.