The NLRP1 and CARD8 inflammasomes detect reductive stress
Q. Wang, J. Hsiao, N. Yardeny, H.-C. Huang, C. M. O'Mara, E. L. Orth-He, D. P. Ball, D. A. Bachovchin
This study identifies chemical probes that induce reductive stress and shows that reductive stress and peptide accumulation together strongly activate NLRP1 and CARD8 inflammasomes.
bioRxiv · Mar 22, 2022Immunology