C. M. Hobson

Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy

This paper introduces a deep learning method to correct optical aberrations in fluorescence microscopy, improving image quality and enabling better downstream analysis.

Nuclear deformation causes DNA damage by increasing replication stress

The paper shows that nuclear deformation during migration or compression causes DNA damage by increasing replication stress, primarily in S/G2 phase, independent of nuclear envelope rupture.

Combined Selective Plane Illumination Microscopy and FRAP maps intranuclear diffusion of NLS-GFP

This paper introduces SPIM-FRAP, a technique combining selective plane illumination microscopy and FRAP to map intranuclear diffusion of NLS-GFP, revealing spatial heterogeneity and validating its accuracy against established methods.

Correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin A/C in nuclear mechanics

The paper uses AFM-LS to correlate nuclear morphology and external force, revealing distinct roles of chromatin and lamin A/C in nuclear mechanics.

Combined Atomic Force Microscope and Volumetric Light Sheet System for Mechanobiology

The paper introduces a combined AFM and light sheet microscope for mechanobiology, enabling high-resolution imaging and force measurements of cellular processes.

VIEW-MOD: A Versatile Illumination Engine With a Modular Optical Design for Fluorescence Microscopy

The paper introduces a modular fluorescence microscope with flexible illumination and imaging modes, demonstrating its use in biosensor imaging, optogenetics, and 3D volume imaging.