Author

J. J. Gruber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. M. Li· 1 shared A. M. Lipchik· 1 shared A. Rangarajan· 1 shared B. He· 1 shared B. S. Geller· 1 shared C. Lu· 1 shared E. B. Rankin· 1 shared H. Jiang· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. M. Li

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Author profile →

2 papers

Recent·Most cited

Serine Starvation Silences Estrogen Receptor Signaling through Histone Hypoacetylation

A. M. Li, Y. Li, B. He, Y. Ramirez, H. Jiang, M.-N. Zhou, C. Lu, J. J. Gruber, E. B. Rankin, J. Ye

The paper shows serine starvation reduces ER expression and histone acetylation in breast cancer cells, linking metabolic stress to chromatin changes and ER pathway inactivation.

bioRxiv · Sep 5, 2021 · PreprintCancer Biology

An acetyl-click screening platform identifies a small molecule inhibitor of Histone Acetyltransferase 1 (HAT1) with anti-tumor activity

J. J. Gruber, A. Rangarajan, T. Chou, B. S. Geller, S. Banuelos, R. Greenhouse, M. Snyder, A. M. Lipchik

This paper identifies a small molecule inhibitor of HAT1, a histone acetyltransferase, showing anti-tumor activity in vitro and in vivo.

bioRxiv · Jun 25, 2021 · PreprintBiochemistry